Archives of Industrial Biotechnology

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Review Article - Archives of Industrial Biotechnology (2021) Volume 5, Issue 1

In vitro susceptibility pattern of clinically isolated klebsiella pneumoniae against beta-lactams, carbapenems, aminoglycosides and quinolones.

Objective: To find the susceptibility pattern of K. pneumoniae against carbapenems, beta-lactams, quinolones and aminoglycosides. Study setting: The study was conducted at Department of Microbiology in Tertiary Care Hospital of Lahore, from July 2016 to December 2019. Materials and methods: A total number of 34,381 samples were collected from several wards of the hospital and processed for microbiological analysis. The organisms were identified by using different microbiological techniques. Antimicrobial resistance profile was determined by Kirby-Bauer disc diffusion method. Results: The positive culture yielded 549 K. pneumoniae. There were 351 (63.9%) male and 198 (36.1%) female patients. The highest number ofK. pneumoniae was isolated from blood samples 236 (43.0%). The highest sensitivity of K. pneumoniae was seen with imipenem 373 (67.9%) followed by 241 (43.2%) to meropenem, 231 (42.1%) to sulbactam/cefoperazone, 227 (41.3%) to amikacin. Less sensitivity of K. pneumoniae was 194 (35.3%) to piperacillin/tazobactam,102 (18.6%) to ciprofloxacin, 66 (12.0%) to moxifloxacin, 50 (9.1%) to co-amoxiclav, 34 (6.2%) to ceftazidime, 31 (5.6%) to cefotaxmine, 30 (5.5%) to ceftriaxone, cefuroxime, 24 (4.5%) to cefixime. Conclusion: Good infection control practices can help to control the spread of K. pneumoniae among the paediatric patients. Carbapenems were found to be more effective in treating K. pneumoniae.

Author(s): Abid Ali*, Nadeem Sharif, Muhammad Arif Khan, Dawood Ahmed, Mirza Zaheer Ud Din Babar Baig, Saera Tufail

Abstract Full Text PDF

Get the App