Journal of Pharmaceutical Chemistry & Chemical Science

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Review Article - Journal of Pharmaceutical Chemistry & Chemical Science (2021) Volume 5, Issue 1

A mini review: Palmitoylethanolamide a cannabimimetic compound with pleiotrophic effects

Palmitoylethanolamide (PEA) is a compound that the body produces naturally to combat pain and inflammation. It’s also being researched as a supplement, though large-scale data are still lacking. Here a brief introduction will be given on PEA and its medical capacity for diverse diseases. PEA is a fatty acid amid like anandamide, the main cannabinoid bliss molecule the body makes. Unlike regular fats, amide-containing fatty acids like PEA and the cannabinoids are directly involved in nerve communication. These molecules are called “neuroactive lipids”. PEA activates the energy-boosting, fat-burning, and anti-inflammatory PPAR alpha. By activating this key protein, PEA stops the activity of pro-inflammatory genes and the production of many inflammatory substances. PEA reduces the activity of the bliss gene FAAH that breaks down natural cannabinoid anandamide. This increases the levels of calming anandamide in the body, helping to combat pain and increase relaxation. It may also activate cannabinoid receptors CB2 and CB1. PEA contains palmitic acid in its structure. The starting point for making PEA in the body is precisely this saturated fatty acid. Many animals and plants also produce PEA. The highest amounts can be found in soy lecithin, soybeans, egg yolk, peanuts, and alfalfa. As a supplement PEA’s co-micronized and ultra-pure forms are available and some co-mixed with luteolin and polydatin.

Author(s): Erhan Yarar*

Abstract Full Text PDF

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