Journal of Gastroenterology and Digestive Diseases

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The frequency and value of intestinal metaplasia in the association of alkaline reflux gastritis and Helicobacter pylori

Background/Aim: Alkaline reflux gastritis is a term used for gastric mucosa damage due to reflux of duodenal and pancreatic content into stomach. The relationship of alkaline reflux gastritis with intestinal metaplasia is also important in addition to many histopathological changes caused by alkaline reflux gastritis. Gastric intestinal metaplasia is a precancerous lesion that requires a follow-up protocol. Materials and methods: This study included 1005 patients who underwent esophagogastroduodenoscopy (EGD) and diagnosed as alkaline reflux gastritis at Endoscopy Unit of Gastroenterology Department of Karabük University, Medical School between January, 2013 and January, 2016. Results: When data of these patients were retrospectively reviewed, intestinal metaplasia was detected in 203 patients (20.2%) whereas Helicobacter pylori in 466 patients (46.4%). Conclusion: In our study, it was found that there was an increase in the frequency of intestinal metaplasia by advancing age, male gender and presence of Helicobacter pylori in patients with alkaline reflux gastritis. This is a retrospective study indicating association of Helicobacter pylori with intestinal metaplasia in patients with alkaline reflux gastritis. We think that there is a need for further prospective studies to investigate presence of intestinal metaplasia in patients with alkaline reflux gastritis.

Author(s): Mehmet Ali Erdogan, Gokan Aksakal, Alpay Aktumen and Burcak Kayhan