Research Journal of Allergy and Immunology

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The correlation between asthma disease and neutrophil to lymphocyte ratio

Purpose: It is shown that neutrophil to lymphocyte ratio (NLR) ((NLR; an indicator of inflammation)) measured in peripheral blood has a contribution in the determination of diagnosis and prognosis in numerous diseases. The purpose of this study was to investigate the correlation between asthma control status and NLR in asthmatic patients, which is a chronic inflammatory disease.

Material and method: 142 patients, who were followed up due to the diagnosis of asthma and had no acute asthma attack, and 104 healthy subjects were included in the study. Respiratory function tests (RFT) was applied to the patients who were followed up due to the diagnosis of asthma. Annual number of attacks, onset age of thedisease, and disease duration were examined. Disease control status was assessed with the asthma control test (ACT). It was categorized as ACT ≥ 20 and ACT<20. The difference between patient and control groups in terms of NLR was examined.

Results: Mean NLR was 2.2 ± 1.2 in the patient group and 1.83 ± 1.02 in the control group. The difference was statistically significant (p=0.005). Also, a significant correlation was found between ACT ≥ 20 and ACT<20 and NLR (p=0.002). There was no statistically significant difference between NLR and RFT values (p>0.05).

Conclusion: Mean NLR was higher in patients with asthma compared to control group. Also as the asthma control status worsened, NLR increased. We think that NLR can be guiding in asthmatic patients together with ACT especially in the assessment of asthma control status.

Author(s): Adil Can Gungen, Yusuf Aydemir