Research Article - Biomedical Research (2018) Volume 29, Issue 3
Relationship of polymorphism of adhesion molecules VCAM-1 and ICAM-1 with preeclampsia
Objective: To investigate relationship of polymorphism of adhesion molecules VCAM-1 and ICAM-1 with preeclampsia.
Method: The present study included 252 patients with PE in our hospital during 2014 February to 2016 December and 200 healthy pregnant women were used as control. Allelic discrimination of the rs5498 polymorphisms of the ICAM-1 gene and rs3181092 of the VCAM-1 gene was assessed using the TaqMan assay. Data was analysed using SPSS 18.0.
Results: In PE patients, both ratios of AA and AA+AG genotypes of VCAM-1 were significantly higher than those in the control group, P<0.05. Comparison of genotypes between PE patients of early-onset and late-onset showed that in late-onset PE patients, ratio of AA genotype in VCAM-1 was significantly higher than that in the early-onset group, P<0.05. Similarly, ratio of genotype AA in severe PE patients was significantly higher than that in mild PE patients, P<0.05. However, in all comparisons, distribution of rs5498 polymorphism of ICAM-1 showed no significant difference in different groups.
Conclusion: Rs3181092 polymorphism of VCAM-1 was associated with occurrence of PE, especially for late-onset and severe PE patients. However whether rs5498 polymorphism of ICAM-1 was associated with PE needed more investigation.Author(s): Ya Chen, Ying Zhang, Yunxia Cao