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Neonatal hyperbilirubinemia and elevated liver enzymes associated with thyroid hormone deficiency in neonates.

During the period January 2004 and December 2009, 5 infants were seen with congenital hypothyroidism and neonatal hyperbilirubinemia and variable degrees of elevated liver enzymes. Hepato-biliary scintigraphy ruled out biliary atresia and infectious causes were excluded by the appropriate investigation. The neonatal hypothyroidism was due to pituitary (central) hypothyroidism (one), transient hypothyroidism (one), thyroid gland aplasia (one), thyroid gland dyshormogenesis (two). The treatment with L-thyroxine led to complete resolution in the liver functions within 2 months.

Author(s): Abdulrahman M. H. Al Nemri, Rushaid N. Al-Jurayyan, Sarar Mohamed, Hessah M. Al Otaibi, Sharifa D. A. Al Eissa, Nasir A.M. Al-Jurayyan