Guillain- Barre syndrome (GBS) is an acute inflammatory demyelination polyrediculoneuropathy which may lead to tetraparasis. GBS mainly affects the peripheral nervous system (PNS) .The present study is an effort to explore the CNS involvement in GBS. A case control study was conducted in North Indian population. 26 subjects with GBS and 30 normal subjects (control) were selected from Department of Medicine, Neurology and Paediatrics, CSMMU, Lucknow. We used Neuro-perfect 2000 EMG/NCV/EP system to collect, analyse, print and store evoked potential data. Result indicates that the mean interpeak latency difference was significantly higher in study group in both Ears. Statistically a significant difference was seen between two groups for both eyes with mean value for latencies in study group being higher as compared to control group. Prolonged central conduction time in Brainstem auditory evoked potentials (BAEPs) and Visual evoked potentials(VEPs) suggest the subclinical auditory and optical pathway involvement in GBS.