Research Article - Biomedical Research (2017) Volume 28, Issue 21
Analysis of relevant risk factor and recurrence prediction model construction of thyroid cancer after surgery
Objective: To explore relevant risk factors of thyroid cancer after surgery, and build prediction of thyroid cancer recurrence.
Methods: Clinical data of thyroid cancer patients who diagnosed by surgical treatment and pathology from June, 2009 to December, 2012 were given retrospective analysis, follow-up for recurrence conditions after surgery; this study used Kaplan-Meier method to calculate recurrence rate after surgery of patients, drew survival curve without recurrence of patients.
Results: This study included 376 cases with thyroid cancer who met conditions, there were 86 male cases, 290 female cases; the age was from 16 to 81 y old. The average age was 43.5 ± 8.1 y old. The follow-up time was from 1 to 58 months. Median follow-up time was 24 h. There were 97 cases (25.8%) with recurrence during follow-up. Survival time without recurrence was from 1 to 58 months. Survival rate without recurrence in the first, second and third year were 96.8%, 92.5% and 87.9% respectively. Multiple factors regression model analysis found that maximum of tumor equal to or more than 4 cm. Surgical mode was unilateral resection of lobe with isthmus. Pathological type was undifferentiated carcinoma. No lymph node dissection was independent risk factors of recurrence of thyroid cancer after surgery (P<0.05). Prediction model was h (t)=h0 exp (3.798 χ1+2.721 χ2+5.972χ3+2.679χ4).
Conclusion: Large tumor size, lobectomy plus isthmectomy, high degree of malignancy histopathology and without lymph node dissection are the main risk factors for thyroid cancer recurrence.Author(s): Shuai Lin, Min Wang, Jingqiang Zhu, Yanchun Gao