Archives of Industrial Biotechnology

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Archives of Industrial Biotechnology 44 7897 074717

Nocturnal Polyuria

Nocturnal polyuria (NP) is a crucial explanation for nocturia and it's associated with an imbalance in water and/or sodium homeostasis. Antidiuretic hormone (ADH) and atrial natriuretic peptide (ANP) are believed to play a crucial role during this excessive urine production overnight, however, many other hormones are involved. ADH and ANP are both directly and indirectly influenced by the renin-angiotensin-aldosterone system (RAAS), prostaglandins antagonize both ADH and RAAS and sex hormones have a predominantly antidiuretic effect by stimulating ADH and RAAS, meaning that any disturbance can lead to an imbalance in diuresis. Since nocturia may be a condition affecting sleep, melatonin secretion also can be affected, resulting in a decrease within the antidiuretic effect and to a rise of nocturnal urine production. Depending on the underlying condition affecting any of these hormones, a more specific therapeutic approach might lead to a restoration of the normal diuresis cycle and to a good night s sleep.

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