Journal of Clinical Oncology and Cancer Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Journal of Clinical Oncology and Cancer Research 44 7897 074717

ONCOLYTIC VIRUS JOURNALS

Oncolytic viruses (OV) are viruses that specifically replicate in cancer cells and thereby destroy cancer tissue but don't harm normal cells (Figure 1). As OVs have a totally new mode of action, they're expected to steer to cancer regression or maybe cure in patients for whom current therapies have failed. To date, several viruses are shown to possess oncolytic properties. Many OVs exert their anti-tumor effect not only by directly lysing the cancer cells, but also by stimulating the anti-cancer immune reaction as a consequence of cell lysis and release tumor specific antigens.
             Thanks to this triple mode of action (cell lysis, systemic anti-cancer immune reaction , local inflammation) and therefore the incontrovertible fact that OV-therapy are often combined with conventional tumor therapies (e.g. chemotherapy, immunotherapy), OVs are exciting and highly promising new anticancer agents. Especially genetically modified OVs, which overcome the restrictions of wild-type viruses, have shown great potential within the treatment of cancer. Efficacy has been shown for several OVs in clinical trials, in order that oncolytic virotherapy has become an accepted new strategy for the treatment of cancer

High Impact List of Articles
Conference Proceedings

Relevant Topics in Clinical Sciences

Get the App