Archives in Food and Nutrition

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Archives in Food and Nutrition 44 7897 074717

Iron Chelation Therapy

Iron is absolutely essential to living cells and plays many essential roles in electricity manufacturing, oxygen shipping and DNA synthesis. Although iron is critical for cells, an excess of iron is toxic. In thalassemia patients, more than one blood transfusions and odd iron absorption cause iron overload and accumulation in tissues and organs. Consequently, reactive oxygen species (ROS) are made from the iron-catalyzed Fenton reaction, inflicting oxidative tissue harm and organ dysfunctions. Iron chelation remedy is required, not just to restore iron balance, but additionally to reduce toxic iron species. Iron chelators, which include desferrioxamine (DFO), deferiprone (DFP) and deferasirox (DFX), are available for clinical use. Due to many side effects and drawbacks of available chelators, novel oral bidentate iron chelator CM1 is synthesized, its miles an analogue and is extra lipophilic than DFP. CM1 became able to bind each ferric and ferrous ion, and was additionally able to chelate plasma non-transferrin sure iron (NTBI), efficiently. CM1 was now not poisonous to peripheral blood mononuclear cells and liver cells in an in vitro study.

High Impact List of Articles
Conference Proceedings

Relevant Topics in Food & Nutrition

Get the App