Journal of Clinical Research and Pharmacy

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Arterial Disease Journals

Peripheral artery disease is a prevalent but underdiagnosed manifestation of atherosclerosis. There is insufficient awareness of its clinical manifestations, including intermittent claudication and critical limb ischemia and of its risk of adverse cardiovascular and limb outcomes. In addition, our inadequate knowledge of its pathophysiology has also limited the development of effective treatments, particularly in the presence of critical limb ischemia. This review targets to highlight only vital elements of the epidemiology and pathophysiology of peripheral artery disease, provides an attention to the often abnormal manifestations of occlusive arterial disease of the lower extremity, enhances awareness of critical limb ischemia, shortly explains the diagnostic role of the ankle brachial index, and check the contemporary management of peripheral artery disease.

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