Addiction & Criminology

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Addiction & Criminology 44 7897 074717

Tumor Necrosis Online Journals

Tumor necrosis factor alpha (TNF-alpha) is an inflammatory cytokine that's released by a spread of cell types, including immune effector cells and tissue-specific cells. TNF-alpha has been shown to promote inflammation via the activation and induction of cytokines interleukin 1 (IL-1), IL-6, and IL-8 and by the upregulation of adhesion molecules on endothelial cells leading to increased leukocyte extravasation. Theoretically, the blockade of TNF should have widespread potential within the treatment of various inflammatory diseases. Presently, 3 TNF-alpha inhibitors obtainable within us are accepted for psoriasis and psoriatic arthritis: infliximab, etanercept, and adalimumab. Numerous case reports and case series are published in recent years reporting the off-label uses of those drugs in various inflammatory skin diseases. This review summarizes the most recent reports on 20 such conditions.

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