Research and Reports in Immunology

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Research and Reports in Immunology 44 7897 074717

Tissue Transplantation Innovations

It was only as recent as 1954 when, after numerous unsuccessful previous attempts, the primary successful kidney transplantation by Murray et al. made human allotransplantation a viable treatment option for terminal organ failure . within the decades that followed, the successful transplantation of all solid organs became a clinical reality . With advancements within the fields of transplantation, immunology, microsurgery, and regenerative medicine, it became possible to increase the sector further and include the transplantation of complex composite tissue allografts, making it feasible to revive the shape and performance of faces, extremities, and lots of other body parts . along side the growing clinical experience, insights about pathophysiological and immunological changes that happen after tissue procurement and upon transplantation are gained. These changes determine allograft survival and performance also as recipient survival. The key players in these processes are identified as ischemia and reperfusion (IR)-related injuries to the transplanted tissue, which may be limited by optimizing the approach to organ preservation within the time between procurement and transplantation

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