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Review Articles Of Clinical Trails

The recent focus of federal funding on comparative effectiveness research underscores the importance of clinical trials within the practice of evidence-based medicine and health care reform. The impact of clinical trials not only extends to the individual patient by establishing a broader selection of effective therapies, but also to society as an entire by enhancing the worth of health care provided. However, clinical trials even have the potential to pose unknown risks to their participants, and biased knowledge extracted from flawed clinical trials may cause the inadvertent harm of patients. Although conducting a well-designed clinical test may appear straightforward, it's founded on rigorous methodology and oversight governed by key ethical principles. during this review, we offer an summary of the moral foundations of trial design, trial oversight, and therefore the process of obtaining approval of a therapeutic, from its pre-clinical phase to post-marketing surveillance. This narrative review is predicated on a course in clinical trials developed by one among the authors (DJM), and is supplemented by a PubMed search predating January 2011 using the keywords “randomized controlled trial,” “patient/clinical research,” “ethics,” “phase IV,” “data and safety monitoring board,” and “surrogate endpoint.” With an understanding of the key principles in designing and implementing clinical trials, health care providers can partner with the pharmaceutical industry and regulatory bodies to effectively compare medical therapies and thereby meet one among the essential goals of health care reform.

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