Journal of Cancer Clinical Research

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Journal of Cancer Clinical Research 44 7897 074717

Oropharyngeal Cancer Review Articles

The epidemiology, diagnosis, and treatment of oropharyngeal cancers are during a state of transition. New models of oncogenesis are under investigation. New imaging and screening methodologies are making early diagnoses more common, and new treatment modalities – and combinations thereof – are proving to possess roles within the management of those cases. Although there has been improved loco regional control of patients afflicted with upper aero digestive tract malignancies, this has not translated into improved overall survival. Human papilloma virus (HPV) infection, and especially type 16 (HPV-16), is now recognized as a big player within the onset of HPV positive OPSCC.  Indeed, the sole sub site within the head and neck with a demonstrated aetiological viral link is, at the present, the oropharynx. These explanations source questions concerning management picks for patients supported tumour HPV status with important consequences on treatment, and on the role of vaccines and targeted therapy over the upcoming years.

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