Journal of Clinical Oncology and Cancer Research

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Journal of Clinical Oncology and Cancer Research 44 7897 074717

NON INVASION BIOMARKER JOURNALS

The use of non-invasive biomarkers within the diagnosis may prevent delays within the diagnosis and treatment of endometriosis. The identification of biomarkers is urgently required for effective and early management, and improvement of the standard of life.
This retrospective case-control biomarker discovery and validation study was conducted within the University College London Hospital, Department of Gynecology.
Women referred for the investigation of pelvic pain, for diagnosis and treatment of endometriosis, then agreed to undergo laparoscopic surgery, were included; “endometriosis”, “controls with pain” and “controls without pain” groups were identified.
A triple approach (chronological & histological dating, and sex steroid determination) was wont to determine the cycle phase. Eutopic and ectopic endometrial tissue samples were collected.
Proteomic analysis by liquid chromatography-mass spectrometry/mass spectrometry was used for protein identification in tissue samples.
Selected differentially expressed candidate markers (LUM, TPM2, CPM, PAEP, TNC), and promising candidate markers reported within the literature (CA125, sICAM1, MCP1, MIF, IL1R2, VEGF, FST) were tested using ELISA kits to spot an efficient non-invasive biomarker for the diagnosis of endometriosis.
The diagnostic performance of every biomarker was statistically determined

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