Journal of Agricultural Science and Botany

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Mancozeb

Mancozeb may be a dithiocarbamate non-systemic agricultural fungicide with multi-site, protective action on contact. it's a mixture of two other dithiocarbamates: maneb and zineb. The mixture controls many fungal diseases during a wide selection of field crops, fruits, nuts, vegetables, and ornamentals. it's marketed as Penncozeb, Trimanoc, Vondozeb, Dithane, Manzeb, Nemispot, and Manzane. In Canada, a mix of zoxamide and mancozeb was registered for control of the mould named Gavel as early as 2008.

Mancozeb reacts with, and inactivates, the sulfhydryl groups of amino acids and enzymes within fungal cells, leading to disruption of lipid metabolism, respiration, and production of ATP .

Mancozeb is listed under FRAC code M:03 The "M:" refers to Chemicals with Multi-Site Activity. "M:" FRAC groups are defined as generally considered as a coffee risk group with none signs of resistance developing to the fungicides.

A major toxicological concern is ethylenethiourea (ETU), an industrial contaminant and a breakdown product of mancozeb and other EBDC pesticides. it's potential to cause goiter, a condition during which the thyroid is enlarged and has produced birth defects and cancer in experimental animals. ETU has been classified as a probable human carcinogen by the EPA.

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