Hematology and Blood Disorders

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Hematology and Blood Disorders 44 7897 074717

HIV HPV Co-infections

The majority of deaths occur in sub-Saharan Africa where rates of opportunistic co-infections are disproportionately high.  These include co-infection with Mycobacterium tuberculosis, Cryptococcus neoformans, hepatitis B virus (HBV), hepatitis C virus (HCV), and Plasmodium falciparum. Finally, we discuss the opportunities and gaps for future research.

 Among HIV-infected individuals, the prevalence’s of HPV infection in the oral, penile, and anal regions have been reported to be higher compared to the general population. Partly attributable to these reasons, HIV-positive individuals have higher risks for anal, oral, and penile cancers. A few older studies have evaluated the effects of Interferon-alpha (IFN-α) treatment on HPV infection and HPV-related dysplasia. Findings from these studies were mixed, but most results were based on the use of standard IFN-α therapy and thus, may not be generalizable to the more recent formulations of IFN-α that are now used to treat Hepatitis C virus (HCV) infection. The purpose of this small pilot study was to assess whether treatment for HCV by pegylated, rather than standard, IFN-α was associated with the presence of or distribution  By examining a small number of high-risk individuals, this study provided further rationale for exploring the possible utility of pegylated IFN-α for prevention of HPV-related disease in high-risk populations.

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