Microbiology: Current Research

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Microbiology: Current Research 44 7897 074717

Glycomics Review Journals

This review presents the present improvements in functional proteomic strategies and their research applications. Proteomics has emerged as an important methodology for large-scale and high-throughput protein analyses within the post-genome era. Functional proteomics, the great analysis of proteins with special attention to their functions, may be a powerful and useful approach for investigations within the life and medical sciences. Various methods are developed for this purpose, expanding the sector further. This important technology won't only provide a wealth of data on proteins, but also contribute synergistically to the understanding of life with other systematic technologies like gene chips.
In this review we list from literature investigations on rat serum proteins using electrophoretic techniques in reference to drug testing. From our own research work, we offer annotated two-dimensional maps of rat serum proteins in check and experimental conditions. Emphasis is on species-specific components and on the consequences of acute and chronic inflammation. We discuss our project of structural proteomics on rat serum as a minimally invasive approach to pharmacological investigation, and that we outline a typical experimental plan for drug testing consistent with the above guidelines. We then report intimately on the results of our trials of anti-inflammatory drugs on adjuvant arthritis, an animal model of disease resembling in many aspects human atrophic arthritis . We demonstrate a correlation between biochemical parameters and therapeutic findings and description the benefits of the chosen methodological approach, which proved also sensitive in revealing “side effects” of the test drugs. In an appendix we describe our experimental protocol when performing two-dimensional electrophoresis of rat serum.

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