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Glomerular Disease Open Access Journals

Management of glomerulonephritis can occur as a primary isolated renal disease, as a manifestation of systemic diseases such as vasculitis or lupus, or secondary to drugs, infections, or tumors. It is an essential cause of morbidity and mortality and a potentially preventable cause of end-stage renal disease, so early diagnosis is vital to allow the timely referral to specialist units where a renal biopsy can be performed. Proteinuria and/or haematuria are typical findings. Pathogenesis involves cells and mediators of the immune system, including the complement pathway. Intrinsic glomerular cells, especially podocytes, are essential in glomerular health problems and the response to it. When nephrotic syndrome is present, it can lead to major morbidity and potential mortality and should be managed, irrespective of the cause, with diuretics, antiproteinuric agents, cholesterol-lowering agents, and, sometimes, anticoagulants.

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