Journal of Pharmacology and Therapeutic Research

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Journal of Pharmacology and Therapeutic Research 44 7897 074717

Scholarly Lipidomics Journals

Membrane lipid composition varies greatly within submembrane compartments, different organelle membranes, and also between cells of various cell stage, cell and tissue types, and organisms. Environmental factors (such as diet) also influence membrane composition. The membrane lipid composition is tightly regulated by the cell, maintaining a homeostasis that, if disrupted, can impair cell function and cause disease. this is often especially pronounced within the brain, where defects in lipid regulation are linked to varied neurological diseases. The tightly regulated diversity raises questions on how complex changes in composition affect overall bilayer properties, dynamics, and lipid organization of cellular membranes. Here, we utilize recent advances in computational power and molecular dynamics force fields to develop and test a realistically complex human brain cell wall (PM) lipid model and extend previous work on an idealized, “average” mammalian PM. The PMs showed both striking similarities, despite significantly different lipid composition, and interesting differences. the most differences in composition (higher cholesterol concentration and increased tail unsaturation in brain PM) appear to possess opposite, yet complementary, influences on many bilayer properties. Both mixtures exhibit a variety of dynamic lipid lateral inhomogeneities (“domains”). The domains are often small and transient or larger and more persistent and may correlate between the leaflets counting on lipid mixture, Brain or Average, also as on the extent of bilayer undulations.

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