Archives of Industrial Biotechnology

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Nuclear Localization Signal

A nuclear localization signal or sequence (NLS) is an amino acid sequence that 'tags' a protein for import into the cell organ by nuclear transport. Typically, this signal consists of 1 or additional short sequences of charged lysines or arginines exposed on the protein surface. totally different nuclear localized proteins could share identical NLS. an NLS has the opposite function of a nuclear export signal (NES), that targets proteins out of the nucleus. These varieties of NLSs are often additional classified as either monopartite or bipartite. the foremost structural variations between a pair of} is that the 2 basic amino acid clusters in bipartite NLSs are separated by a comparatively short spacer sequence (hence bipartite - 2 parts), whereas monopartite NLSs are not.

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