Journal of Neuroinformatics and Neuroimaging

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Journal of Neuroinformatics and Neuroimaging 44 7897 074717

Neuromuscular Transmission

Neuromuscular transmission block due to an injury of the peripheral nerve appears in the early stages of reinnervation. In microelectrode methods, miniature end-plate potentials (MEPPs) were of normal amplitude but of decreased frequency. The quantum content of the end-plate potential (EPP) decreased significantly, while the quantum size of the EPP was within normal limits. The time course of the EPPs was remarkably prolonged despite the normal time course of MEPPs. Abnormal end-plate responses returned to normal after day 40. Neuromuscular transmission block in the early stages of reinnervation could best be explained by a failure of an impulse to invade the axon terminal.

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