Journal of Clinical and Experimental Toxicology

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Journal of Clinical and Experimental Toxicology 44 7897 074717

Mitochondrial Toxicity

Mitochondrial toxicity is progressively familiar as a contributor to drug-induced injuriousness of a variety of drug programs leading to opaque box warnings and even late-stage arcade withdrawals. Such off-target mitochondrial toxicity can disturb a diversity of organs, such as liver, heart, muscle, kidney, and central nervous system. The challenging is that it is difficult, if not unbearable, to detect in preclinical innate representations and in humans it is frequently characteristic, and hence not revealed until great populations have been unprotected. Preclinical in vitro challenging can reduce drug-induced mitochondrial toxicity. Here we define some in vitro examines and discuss a novel model of idiosyncratic toxicity based on mitochondrial damage

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