Archives of Digestive Disorders

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Archives of Digestive Disorders 44 7897 074717

Hematopoietic Stem Cells Open Access Journals

Hematopoietic stem cells (HSCs) are multipotent, self-renewing progenitor cells that develop from mesodermal hemangioblast cells. All differentiated blood cells from the lymphoid and myeloid lineages arise from HSCs. HSCs can be found in adult bone marrow, peripheral blood, and umbilical cord blood. Classic studies in mice describe two populations of Hematopoietic Stem Cells, Long Term and Short Term. Long term HSCs are capable of self renewal, while short term HSCs do not have this capacity. Short term HSCs, also known as progenitor or precursor cells, can differentiate into all types of blood cells, which can be characterized by specific markers. Haematopoietic stem cells are progenitor cells that have the ability to both generate all types of blood cells, including those of the myeloid and lymphoid lineages, and to replace themselves. In adults, they mainly reside in the bone marrow.

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