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Matrix microenvironment mediated fate determination of stem cells

Joint Event On World Congress on Tissue Engineering, Stem Cells and Regenerative Medicine & International Conference on Cell and Gene Therapy
March 14-15, 2019 | London, UK

Ming Pei

West Virginia University, USA

Keynote : Biomed Res

DOI: 10.4066/biomedicalresearch-C1-024


Adult stem cells are a promising cell source for tissue regeneration. Due to the limited size of biopsy which provides small amount of stem cells, ex vivo expansion is necessary for acquiring a large quantity of stem cells with differentiation capacity. Unfortunately, in vitro expansion in 2D renders the cells senescent. Recently, decellularized extracellular matrix provides a 3D matrix microenvironment to efficiently expand tissue-specific stem cells for tissue engineering and regeneration. This matrix microenvironment can not only promote stem cell proliferation capacity but also determine lineage preference of adult stem cells. Despite the necessity for further in-depth investigation, this 3D matrix might bring the potential for future tissue engineering and regeneration.


Ming Pei completed his PhD from Beijing University, China and postdoc training from Harvard-MIT Division of Health Sciences and Technology, USA. Currently, he is a tenured professor and director of stem cell and tissue engineering laboratory in the Department of Orthopaedics, West Virginia University, USA. He has over 100 publications that have been cited over 3100 times and his publication h-index is 32 and has been serving as an editorial board member of reputed Journals. 


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