Hematology and Blood Disorders

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Hematology and Blood Disorders 44 7897 074717

Haemodilution

Hemodilution induces macro- and microcirculatory responses, allowing the adaptation of the organism to the dilution-associated reduction in the oxygen content of the blood. While the cardiovascular response consists mainly of an increase in cardiac output and organ blood flow – normovolemia provided – the microcirculation responds with an increase of red blood cell velocity, more homogeneous distribution of microvascular flow, and well-maintained functional capillary density and tissue oxygenation. Extreme hemodilution is tolerated if the microcirculatory function is preserved by the elevation of plasma viscosity and thus higher shear stress on the microvascular wall. Hyperoxic hemodilution may be considered an effective method to make use of extreme hemodilution in the clinic.

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