International Journal of Respiratory Medicine

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International Journal of Respiratory Medicine 44 7897 074717

Circulating Angiotensin

Angiotensin converting enzyme (ACE) gene contains a polymorphism, consisting of either the presence (I) or absence (D) of a 287 nucleotide fragment. Deletion (D) is related to increased circulating ACE (cACE) activity. it's been suggested that the D-allele of ACE genotype is related to power-oriented performance which cACE activity is correlated with muscle strength. Respiratory muscle function could also be similarly influenced. Respiratory muscle strength in infants are often assessed specifically by measurement of the utmost inspiratory pressure during crying (Pimax). Pressure-time index of the respiratory muscles (PTImus) may be a non-invasive method, which assesses the load to capacity ratio of the respiratory muscles.

The objective of this study was to work out whether increased cACE activity in infants might be associated with greater respiratory muscle strength and to research the potential association of cACE with PTImus measurements also because the association of ACE genotypes with cACE activity and respiratory muscle strength during this population.

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