Journal of Cancer Immunology & Therapy

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Journal of Cancer Immunology & Therapy 44 7897 074717

Cancer Applications

During the past decades, many studies have provided evidence for a task of laminin-binding integrins in tumorigenesis, both tumor-promoting and suppressive activities. As a serious component of the basement membrane that forms the somatic cell niche (Rodin, 2014) and since of the central role within the regulation of cancer stem cells (Qin, 2016), laminin/integrin-mediated interactions is of high therapeutic interest in cancer treatment (Rabinovitz & Mercurio, 1997; Berg, 2016). Cancer stem cells (CSCs) represent a subset of tumor cells that typically exhibit the power to self-renewal and sometimes have multi-potent capabilities. The expression of varied laminin subunits within the tumor microenvironment surrounding the CSCs subpopulation has been demonstrated to function a distinct segment for CSCs and contribute to tumor progression

In a publication in Nature Cancer  the authors show that L1CAM+ cells in human colorectal cancer (CRC) have metastasis-initiating capacity, and that they define their relationship to tissue regeneration. They confirmed that L1CAM bound heterophilically to laminins known to be expressed within the intestinal and endothelial cell basement membranes additionally to exhibiting homophilic interaction with L1CAM itself. L1CAM knockdown inhibited the power of CRC organoid-derived cells to bind to laminin-coated plates

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