Biology & Medicine Case Reports

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Biology & Medicine Case Reports 44 7897 074717

BIOMARKER DISCOVERY JOURNALS

Biomarker discovery may be a medical term describing the method by which biomarkers are discovered. Currently available biomarkers, like those wont to diagnose myocardial infarct (e.g., cardiac troponins), were identified within the course of targeted physiologic studies. Similarly, basic investigation of diseases has largely been characterized by studies of isolated molecules in cellular systems.,

 Laterza et al. used such a worldwide survey, and during this issue of Clinical Chemistry they describe their discovery of potential new markers related specifically to brain injury. Now begins the long road toward validation of those markers in clinically relevant human cohorts. Although no serum biomarkers of brain injury for conditions like stroke are in clinical use, they might ultimately convince be of enormous clinical usefulness to enrich physical and radiologic examinations, both of which may be ambiguous during acute presentations.

Consideration of the remaining steps underscores the tenuous road to discovery of biomarkers that are useful, a road which will be better illuminated when the complementary powers of transcriptional profiling and proteomics reach similar maturity. Their efforts so far suggest tantalizing novel markers of diseases of the brain and therefore the refore the beginning of an extended journey toward the identification of a clinical biomarker and the arduous transition from the research environment to routine clinical practice

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