Archives of General Internal Medicine

Archives of General Internal Medicine 44 7897 074717

Top Open Access Journals In Pulmonology

Pulmonology is a neighborhood of drugs that focuses on the health of the systema respiratorium. s treat everything from asthma to tuberculosis Oxidative stress from oxidative metabolism causes base damage, also as strand breaks in DNA. Base damage is usually indirect and caused by reactive oxygen species (ROS) generated, e.g. O2− (superoxide radical), OH (hydroxyl radical) and H2O2 (hydrogen peroxide). However, excess ROS production can damage lipids, DNA, and proteins which may cause necrobiosis. ROS-induced damage underpins various oxidative stress-related human diseases and aging. In addition, the cellular antioxidant defenses may decrease during aging which lands up in age-related increase of ROS and oxidative stress. Excess ROS also can activate the proinflammatory signaling pathways and therefore the release of multiple inflammatory mediators, like cytokines, chemokines, eicosanoids, et al. . Therefore, oxidative stress is implicated in the pathogenesis, development, and progression of a sustained inflammatory state.

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