Archives of General Internal Medicine

Upcoming Special Issues

  • Zelada Castro

    Internist at Louis A Weiss Memorial Hospital, USA

Covid-19 and its variants - Antidrugs

Special Issue Information

A high rate of morbidity and mortality has been observed worldwide as a result of the COVID-19 (coronavirus) pandemic. Currently, there is no available effective treatment. Many clinical trials with antiviral and other drugs are in progress, but the availability of an effective vaccine or the development of experimental drugs is not considered feasible for this year. The economic decline from the emergency restrictions is likely to cause unprecedented damage to living standards, including decline in healthcare systems and increases in morbidity and mortality worldwide, especially in developing countries. Emergency strategies and medicines are required to combat the COVID-19 pandemic, including unconventional approaches. There are many pathways involved in the initiation and progression of the COVID-19 infection, and many more associated with the severe acute respiratory syndrome (SARS) and other symptomatological side effects. The aim of this Special Issue is to propose possible therapeutics and the related mechanisms for targeting one or more pathways to combat the progress of the COVID-19 disease and/or associated symptoms. The proposal for therapeutics is only related to regulatory approved drugs and should include the INN name, mode of action, posology, therapeutic index, toxic side effects, ADMET characteristics, patient categories receiving the drug, drug interactions and use in adjuvant therapies. It is hoped that the findings and strategy adopted in this Special Issue will encourage clinical trials and the compassionate use of promising therapeutics against the COVID-19 infection

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Archives of General Internal Medicine is an international peer-reviewed open access quarterly journal published by allied academies.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English.



  • drug design, development and use
  • COVID-19 drugs
  • SARS-CoV-2
  • multi-target drugs
  • antiviral drugs
  • drugs for COVID-19 symptomatology
  • repurposing drugs
  • prophylactic drugs
  • emergency medicines
  • combination therapies
  • adjuvant therapies
  • drug risk/benefit assessment
  • compassionate use of drugs
  • ADMET of drugs

This special issue is now open for submission.