Allied Journal of Medical Research

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Allied Journal of Medical Research 44 7897 074717

Size Exclusion Chromatography Review Articles

Size exclusion chromatography (SEC), also called gel permeation chromatography within the case of lipophilic macromolecules or gel filtration chromatography within the case of hydrophilic macromolecules, is at the present far and away the most common method for separation and molecular characterization of synthetic polymers. SEC is additionally widely
used for separation of varied natural polymers and for the purification of complex samples. the tactic is fast, simple, rather cheap, and well repeatable. Sample consumption for
analytical purposes is little . Usefulness of SEC is gigantic because it enables right exact determination of molar masses and molar mass distributions of linear homopolymers, assessment of molecular parameters of branched polymers, assignment of sizes of isolated macromolecules in solution, also as of magnitude of their possible aggregation and association. Diffusion rate of macromolecules in porous bodies, and molar masses and molar mass distributions of complex polymers, for instance various kinds of copolymers are often estimated and therefore the extent of (preferential) interactions within the macromolecular systems can be judged. SEC practically fully substituted numerous
classical methods of separation and molecular characterization of macromolecules like the solubility-based fractionation, static light scattering, both vapour pressure and membrane osmometries, ebulliometry, and cryometry, diffusion measurements, ultracentrifugation, and partially also conventional viscometry. Unfortunately SEC is usually used improperly because several phenomena which will badly affect the standard of results are unknown, underestimated, overlooked, or deliberately ignored by many users of the method.

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