Journal of Pharmacology and Therapeutic Research

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Journal of Pharmacology and Therapeutic Research 44 7897 074717

Research Articles Of Drug Discovery

Natural products and their derivatives have historically been invaluable as a source of therapeutic agents. However, within the past decade, research into natural products within the pharmaceutical industry has declined, due to issues like the shortage of compatibility of traditional natural-product extract libraries with high-throughput screening. However, as discussed during this review, recent technological advances that help to deal with these issues, including unrealized expectations from current lead-generation strategies, have led to a renewed interest in natural products in drug discovery.
 

Chemical substances derived from animals, plants and microbes are a serious source of lead compounds for the pharmaceutical industry; of the 877 small-molecule New Chemical Entities (NCEs) introduced between 1981 and 2002, ∼49% were natural products, semi-synthetic natural product analogues or synthetic compounds supported natural-product pharmacophores.
 

Despite this success, pharmaceutical research into natural products has experienced a slow decline during the past 20 years .
The decreased emphasis within the pharmaceutical industry on the invention of natural products are often attributed to many factors, including:

 

the introduction of high-throughput screening against defined molecular targets, which prompted many companies to maneuver from natural-product extract libraries towards 'screen friendly' synthetic chemical libraries.
 

the development of combinatorial chemistry, which initially offered the prospect of simpler, more drug-like screening libraries of wide chemical diversity advances in biology , cellular biology and genomics, which increased the amount of molecular targets and prompted shorter drug discovery timelines.

 

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