Allied Journal of Medical Research

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Allied Journal of Medical Research 44 7897 074717

Post-mortem Drug Top Open Access Journals

Postmortem drug concentrations in blood might not all the time reflect antemortem drug concentrations in blood because of the movement of the drugs after death. This incident is referred to as Postmortem Redistribution. Mechanisms involved in postmortem redistribution are both complicated and poorly understood. However, postmortem drug concentrations in blood do track some usually accepted trends that help with interpretation; the characteristics of the drug itself can be utilized to show if a drug is subject to PMR. Major changes in blood drug concentrations are anticipated for basic, lipophilic drugs with a high volume of dissemination. When PMR occurs, blood specimens drawn from the central body cavity and heart generally will have higher drug concentrations postmortem than specimens drawn from peripheral areas, most commonly the femoral vein. The dispersion of drugs from organ tissue into the blood might explain the seen phenomenon.

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