Hematology and Blood Disorders

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Hematology and Blood Disorders 44 7897 074717

PLATELET ACTIVATING FACTOR JOURNAL

Platelet-activating factor, also referred to as PAF, PAF-acether or AGEPC (acetyl-glyceryl-ether-phosphorylcholine, is involved in changes to vascular permeability, the oxidative burst, chemotaxis of leukocytes, also as augmentation of arachidonic acid metabolism in phagocytes.

PAF is produced by a spread of cells, but especially those involved in host defense, like platelets, endothelial cells, neutrophils, monocytes, and macrophages.
PAF is employed to transmit signals between neighboring cells and acts as a hormone, cytokines, and other signaling molecules. PAF are often used as an area signaling molecule and travel over very short distances or it are often circulated throughout the body and act via endocrine.
 This has been demonstrated within the skin of humans and within the paws and skin of lab rabbits and rodents. The inflammatory response is enhanced by the utilization of vasodilators, including prostaglandin E1 (PGE,) and PGE2 and inhibited by vasoconstrictors.
PAF also induces apoptosis during a different way that's independent of the PAF receptor. The pathway to apoptosis are often inhibited by feedback from PAF acetylhydrolase (PAF-AH), an enzyme that catabolizes platelet-activating factor.
It is a crucial mediator of bronchoconstriction. At a degree of 10−12 mol/L, PAF causes life-threatening inflammation of the airways to induce asthma like symptoms.
Toxins like fragments of destroyed bacteria induce the synthesis of PAF, which causes a drop by vital sign and reduced volume of blood pumped by the guts , which results in shock and possibly death.

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