Biology & Medicine Case Reports

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Biology & Medicine Case Reports 44 7897 074717

NEURONAL MARKER JOURNALS

Obesity has grown to epidemic proportion throughout the planet . Its complications include diabetes, cardiovascular diseases and chronic diseases. However the precise pathophysiology of obesity remains unclear. Excessive food intake seems to play a task within the development of obesity. Role of hypothalamus within the control of food intake has been well-documented. However, human studies on eating behaviors indicated that hypothalamus may receive input from other brain regions, particularly from cortex. Using positron emission tomography (PET) scan, we investigated brain responses (by measurements of regional cerebral blood flow (rCBF), marker of neuronal activity) to the meal stimulations in certain population like lean, obese subjects, and lean people that has history of severe obese but successfully maintained weight loss (former obese). leads to lean individuals indicated that satiety was related to increases rCBF within the left dorso-lateral prefrontal cortex (LDLPC). In comparisons of brain responses to a meal between lean and obese individuals, we found that lesser activation within the LDLPFC was observed in obese individual in comparison to lean individual no matter meal size. additionally , normalized neuronal activity during this area has been observed in former obese individuals. last , differential response of neuronal activity within the LDLPFC could also be either an acquired feature of obesity that reverses with successful weight loss or an inherent feature in those people that are ready to successfully maintain weight loss. Our findings also indicate that the LDLPFC might be a target for future interventions aimed toward modulating eating behavior.(Duc Son Nguyen Trung L, Role of neuronal markers within the pathophysiology of obesity)

 

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