Journal of Cell Biology and Metabolism

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Journal of Cell Biology and Metabolism 44 7897 074717

Murine B Cell Development

B1 cells are first produce in the fetus and most B1 cells undergo self-renewal in the periphery, unlike conventional B cells (B2 cells) that are produced after birth and replaced in the bone marrow. B1 cells are a sub-class of B cell lymphocytes that are intricate in the humoral immune response. They are not part of the adaptive immune system, as they have no memory, but other else, B1 cells perform many of the same roles as other B cells: making antibodies against antigens and acting as antigen-presenting cells. These B1 cells are commonly found in peripheral sites, but fewer commonly found in the blood. These cells are involved in antibody response during an infection or vaccination. There are two types of B1 cells subsets, one is B1a cells and other one is B1b cells. B1b cells have been shown to be capable of memory response.  B1b cells also can recognize protective antigens in bacteria, which is unique because they are targeting something internal.

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