Microbiology: Current Research

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Microbiology: Current Research 44 7897 074717

MetallobetalactamaseNDM Scholarly Peer-review Journal

The NDM-1 protein product itself doesn't cause disease, but it's the potential to vary the characteristics of bacteria. The gene makes bacteria resistant to antibiotics. In this way, it can lead to a range of conditions, such as a urinary tract, bloodstream, or wound infections and pneumonia. Carbapenems are among the most powerful antibiotics. Healthcare professionals use them as a final resort for several bacterial infections, like people who E. coli and Klebsiella pneumoniae cause. The NDM-1 gene allows the bacterium to supply an enzyme that neutralizes the activity of those antibiotics. The Centers for Disease Control and Prevention (CDC) has classified NDM-1 and another similar protein called KPC as emerging issues within the field of infectious diseases. The NDM-1 protein is different from the protein product which characterizes methicillin-resistant Staphylococcus aureus (MRSA), another superbug. MRSA are a Gram-positive bacteria, while the bacteria that carry NDM-1 are Gram-negative, a special classification of bacteria.

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