Hematology and Blood Disorders

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Hematology and Blood Disorders 44 7897 074717

Mammalian Fertilization:

Only the capacitated spermatozoa interact with the extracellular coat, the zona pellucida, which surrounds the mammalian oocyte. The tight and irreversible binding of the opposite gametes in the mouse and many other mammals studied, including human, starts a ca2+- dependent signal transduction pathway.Factors that regulate the penetration of the zona pellucida and fusion of the opposite gametes.

The principles of mammalian fertilization are defined in relation to studies of the intracytoplasmic injection of spermatozoa into human oocytes (ICSI). Current concepts in gametogenesis are discussed, including spermiogenesis, oogenesis, the biology and penetration of the zona pellucida including capacitation and the acrosome reaction, gamete fusion, the block to polyspermy and growth of the pronucleus. A concluding section relates the normal events of fertilization to those occurring after ICSI and discusses various types of anomalies found in the oocyte after ICSI.

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