Allied Journal of Medical Research

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Allied Journal of Medical Research 44 7897 074717

Impact Factor Of Drug Discovery

Peptides are recognized for being highly selective and efficacious and, at an equivalent time, relatively safe and well tolerated. Consequently, there's an increased interest in peptides in pharmaceutical research and development (R&D), and approximately 140 peptide therapeutics are currently being evaluated in clinical trials. as long as the low-hanging fruits within the sort of obvious peptide targets have already been picked, it's now become necessary to explore new routes beyond traditional peptide design. samples of such approaches are multifunctional and cell penetrating peptides, also as peptide drug conjugates. Here, we discuss the present status, strengths, and weaknesses of peptides as medicines and therefore the emerging new opportunities in peptide drug design and development.
More than 7000 present peptides are identified, and these often have crucial roles in human physiology, including actions as hormones, neurotransmitters, growth factors, ion channel ligands, or anti-infectives 1, 2, 3, 4. generally , peptides are selective and efficacious signaling molecules that bind to specific cell surface receptors, like G protein-coupled receptors (GPCRs) or ion channels, where they trigger intracellular effects. Given their attractive pharmacological profile and intrinsic properties, peptides represent a superb start line for the planning of novel therapeutics and their specificity has been seen to translate into excellent safety, tolerability, and efficacy profiles in humans. This aspect may additionally be the first differentiating factor of peptides compared with traditional small molecules. Furthermore, peptide therapeutics are typically related to lower production complexity compared with protein-based biopharmaceuticals and, therefore, the assembly costs also are lower, generally approaching those of small molecules. Thus, in several ways, peptides are within the sweet spot between small molecules and biopharmaceuticals.

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