Journal of Clinical Nephrology and Therapeutics

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Idiopathic Membranous Nephropathy

Idiopathic membranous nephropathy is still the most common glomerular disease associated with the nephrotic syndrome. The greater the proteinuria, greater the long-term risk for renal failure. Additionally, the patients who have the membranous nephropathy with nephrotic syndrome have the significant morbidity and mortality, in particular related to thromboembolic and the cardiovascular complications. Immuno-suppressive treatment options include the use of cortico-steroids, alkylating agents, cyclosporine A, tacrolimus, and the mycophenolate mofetil, but their use is controversial, not all have been shown to be effective, and their use can be associated with the significant adverse effects. This has to be resulted relatively to small improvement in the prognosis of the membranous nephropathy in the past 30 yr, with up to 40% of patients eventually reaching the end-stage renal failure. Agents that will offer more complete response rates with lower adverse effects are truly needed.

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