Insights in Nutrition and Metabolism

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Insights in Nutrition and Metabolism 44 7897 074717

CYCLOOXYGENASE Enzyme

Cyclooxygenase (COX) may be a rate-limiting enzyme involved within the conversion of arachidonic acid to prostaglandin H2, which is that the precursor of several molecules, including prostaglandins, prostacyclin, and thromboxanes.
A member of the animal-type heme peroxidase family, it's also referred to as prostaglandin G/H synthase. the precise reaction catalyzed is that the conversion from arachidonic acid to Prostaglandin H2, via a short-living Prostaglandin G2 intermediate.

Pharmaceutical inhibition of COX can provide relief from the symptoms of inflammation and pain. nonsteroidal anti-inflammatory drug drugs (NSAIDs), like aspirin and ibuprofen, exert their effects through inhibition of COX. people who are specific to the COX-2 isozyme are called COX-2 inhibitors. The active metabolite (AM404) of paracetamol believed to supply most or all of its analgesic effects may be a COX inhibitor, and this is often believed to supply a part of its effect.[5]

In medicine, the basis symbol "COX" is encountered more often than "PTGS". Thus, the 2 isozymes found in humans, PTGS1 and PTGS2, are frequently called COX-1 and COX-2 in medical literature.

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