Journal of Cancer Clinical Research

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Cancer Immunotherapy Research Articles

Cancer immunotherapy (therapy that uses an individual's system to fight cancer) has become a crucial field of oncology. There are four key kinds of immune-therapies: mono-clonal antibodies; cancer vaccines; check point inhibitors; and non-specific cancer immune-therapies (therapies that don't target cancer specifically, but stimulate immune cells that can cause anti-cancer immune reaction , like interleukins, cytokines, inter-ferons, and others). Tumors express ligands to immune checkpoint proteins, such as PD-1 (programmed cell death 1) and CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), mediating block of immune response. Thus, the development of inhibitors of these immune checkpoint pathways is a promising area of immune therapeutics. In addition, tumors express tumor antigens that can be targeted with antibodies; antibody-drug conjugates; chimeric antigen receptor (CAR) T cells; or by other approaches. Dendritic cell inoculation is additional significant immunotherapy method beside cancer. This Special Issue is focused on recent immunotherapy approaches, novel immune therapeutics, and immunology signaling pathways in cancer.

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