Journal of Biochemistry and Biotechnology

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Akylating Exogenous Agents

Alkylating agents (ATC code L01A) ar extremely reactive compounds that simply attach to DNA and cellular proteins. the first mode of action for many alkylating medication is via cross-linking of DNA strands. they'll be classified as either monofunctional alkylating agents, implying reactions with only one strand of DNA, or bifunctional alkylating agents, that cross-link 2 strands of DNA. Replication of DNA and transcription of rna are prevented by these cross-links.Many alkylating agents are developed (Table 2). although these drugs have similar mechanisms of action, there are major variations in spectrum of activity, pharmacokinetic parameters, and toxicity. Alkylating agents play a significant role within the treatment of lymphoma, hodgkin's disease, breast cancer, multiple myeloma, and other malignancies. additionally to conventional chemotherapy, the linear dose–response curve of alkylating agents expands their role for incorporation into transplant regimens.

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