Archives of General Internal Medicine

Archives of General Internal Medicine 44 7897 074717

Acute Hepatitis C

Symptomatic acute hepatitis C takes place in only around 15% of patients who are already suffering with hepatitis C virus (HCV). Acute hepatitis C is usually diagnosed in the setting of post-exposure surveillance or seroconversion in high-risk individuals before known to be seronegative. Even though transmission via transfusion and injecting drug use has refused in developed countries, dangerous blood products and medical practices continue to improve transmission of HCV in various developing countries. Clinically, acute hepatitis C can enhance concentrations of alanine aminotransferase to more than ten times the upper limit of normal however nearly never causes fulminant hepatic failure. Symptomatic patients with jaundice have a higher likelihood of spontaneous viral clearance than do asymptomatic patients, and thus should be monitored for at least 12 weeks before initiating antiviral therapy.

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