Biology & Medicine Case Reports

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Biology & Medicine Case Reports 44 7897 074717

Zinc Metabolism

Zinc, although present during a minute quantity in humans, is an important nutrient with three major biological roles, as catalyst, structural, and regulatory ion. It plays a crucial role as a component of the many enzymes regulating cell growth, protein synthesis, energy metabolism, gene transcription, hormone levels, and protein metabolism. Zn affects somatotropin (GH) metabolism which is that the key hormone for growth and development. Zn ion induces the dimerization of GH within the way that two Zn ions associate per dimer of GH during a cooperative fashion. Formation of a ZnGH dimeric complex could also be important for storage of GH in secretary granule. Zinc is reported to influence hemostasis by affecting platelet aggregation and coagulation. Zn enhances thrombin activity of the common coagulation pathway, the acceleration of fibrin polymerisation, platelet activation and therefore the initiation of the intrinsic pathway. deficiency disease was an explanation for growth retardation and delayed sexual development in men. Zn content of the prostate, the semen and ejaculated sperm are very high and testicular Zn is important for spermatogenesis. Zn deficiency has also been reported to be an explanation for hypogonadism. (Ibrahim NL- Study of Serum Copper and Iron in Children with Chronic Liver Diseases).

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