Journal of Cancer Immunology & Therapy

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Journal of Cancer Immunology & Therapy 44 7897 074717

Suicide Gene Therapy Journals

Since conventional cancer treatments aren't ready to cure approximately 50% of cancers in patients, novel therapies must be developed. variety of various cancer gene therapy protocols are currently underway, including those using suicide genes. Gene therapy provides one approach by which tumors that are immune to conventional agents could also be treated. Inserting a suicide gene into tumor cells will cause tumor necrobiosis upon exposure to a prodrug, even in chemotherapy resistant tumor cells. One major limitation to using gene therapy for cancer is that modification of a whole tumor isn't possible and untreated cells can grow back to tumors. However, the HSV-TK/GCV system features a critical advantage, since the gene-modified cells are toxic to nearby unmodified cells when exposed to the prodrug. This has been termed the “bystander effect”. Although the mechanism of this “bystander effect” is complex, the in vitro mechanism relies on transfer of toxic metabolites from gene-modified to unmodified cells, while the in vivo mechanism appears to be more complex and associated with chemosensitization, hemorrhagic tumor necrosis, and activation of immune reaction.

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