Reports on Oral Diseases

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Reports on Oral Diseases 44 7897 074717

Scientific-journals-on-pharmacokinetics

AIDS Care addresses the psychosocial aspects of AIDS through research in disciplines such as psychology, sociology, epidemiology, social work, ethics, education, etc.This journal highlights existing theoretical models of AIDS education and prevention, including model development, implementation, and evaluation.The scope of the journal highlights the advanced topics in drug development, HIV vaccines, pre-exposure prophylaxis, or post-exposure prophylaxis, Post-exposure prophylaxis, Sex Education, HIV/AIDS Denialism, AIDS Dementia Complex, rural livelihoods, stigma, patient oriented research studies.The Journal of HIV and AIDS (JHA) focuses on remarkable advances in our understanding of HIV science and its clinical evolution and management alternatives, comprising anti-retroviral and palliative therapies, and public health policies to contain the viral spread. The Journal editors are particularly interested in the latest breakthroughs in the diagnosis and therapy of HIV/AIDS immunological syndrome.Besides, the editors are interested in the practical application of the current understanding of that knowledge to clinical practice and the challenges to deliver those to the public.

All analyses were performed using SPSS software version 19.0 and findings were compared using the appropriate statistical tests. The median change from baseline to the most recent CD4 cell count was 141 cells/μl. By 5 years, the overall median CD4 cell count was 472 cells/μl while the median CD4 cell count was 401 cells/μl among patients with baseline CD4 cell counts ≤100 cells/μl, 467 cells/μl among those with baseline CD4 cell counts of 100 to 199 cells/μl, and 586 cells/μl among those with baseline CD4 cell counts equal to greater 200 cells/μl. At the end of the study, patients with higher baseline CD4 cell stratum returned to normal CD4 cell counts compared to those with the least baseline CD4 cell stratum. The findings suggest that consideration be given to initiation of ART at a CD4 cell count >350 cells/μl to achieve better immune recovery.

 

It emphasizes on absorption, distribution metabolism and excretion of the drugs.drugs (drug-drug pharmacokinetics), Clinical papers that include population pharmacokinetic-pharmacodynamic relationships are welcome. After absorption, the drug is distributed to tissues via the blood, including kidney and liver, and excreted into the urine and bile. Highly lipophilic drugs, generally considered to exhibit a high pharmacological activity, are often metabolized by drug-metabolizing enzymes and converted to more hydrophilic metabolites for excretion. Given that metabolism is a key factor in lipophilic drug elimination, identification of the respective drug-metabolizing enzymes can lead to a better understanding of the pharmacokinetics of new drugs. Pharmacokinetics is therefore regarded as one of the most essential processes in new drug research and development to maximize drug efficacy and avoid the risk of interactions with concomitant drugs or inter-individual differences. This paper summarizes experiences linked with the identification of non-P450 enzymes in Daiichi Sankyo, based on: 1) drug interaction: acyl peptide hydrolase involved in the interaction of valproic acid with a combination of carbapenem antibiotics, and alcohol dehydrogenase 4 involved in tivantinib metabolism.

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